How iron can drive neurodegeneration

Boyd Kenkhuis; Ashley I Bush; Scott Ayton

doi:10.1016/j.tins.2023.02.003

How iron can drive neurodegeneration

Trends Neurosci. 2023 May;46(5):333-335. doi: 10.1016/j.tins.2023.02.003. Epub 2023 Feb 24.

Authors

Boyd Kenkhuis¹, Ashley I Bush², Scott Ayton³

Affiliations

¹ Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands; Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
² Florey Institute of Neuroscience and Mental Health and the University of Melbourne, Parkville, Victoria 3052, Australia. Electronic address: ashley.bush@florey.edu.au.
³ Florey Institute of Neuroscience and Mental Health and the University of Melbourne, Parkville, Victoria 3052, Australia. Electronic address: scott.ayton@florey.edu.au.

PMID: 36842947
DOI: 10.1016/j.tins.2023.02.003

Abstract

Iron overload in neurodegenerative diseases is well established but of uncertain significance. In a recent article, Ryan et al. reveal that microglia are especially vulnerable to iron overload-induced ferroptosis. Their evidence for microglial ferroptosis in clinical specimens indicates that ferroptosis inhibitors may hold therapeutic promise for these diseases.

Keywords: Alzheimer's disease; Parkinson's disease; astrocytes, iPSC; ferroptosis; microglia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Iron
Iron Overload*
Microglia
Neurodegenerative Diseases*

Substances

Iron