MMPs, ADAMs and ADAMTSs are associated with mammalian sperm fate

Abstract

Metalloproteinases include matrix metalloproteinases and disintegrin metalloproteinases. They are important members of the ECM degradation and reconstruction process and are associated with tissue development and disease. The ECM is a three-dimensional network of large molecules consisting of a variety of proteins. It is a physical scaffold for organs, and all types of cells can be found within the ECM. The testicle, where sperm are produced, is an organ that is constantly in dynamic flux. Metalloproteinases can regulate testicular tissue development and the maturation of sperm by affecting the ECM. Metalloproteinase disorders can lead to cryptorchidism, azoospermia, poor semen quality and other diseases. As a member of the metalloproteinase family, ADAMTS plays an important role in testicular slippage to the scrotum. ADAM is involved in the fertilization process, and excessive MMP can damage the BTB. In the testis, metalloproteinase stability represents the stability of the extracellular microenvironment in which germ cells are located and is associated with reproductive function. Metalloproteinases have a definite relationship with male reproduction, but the underlying mechanism is still unclear. This paper summarizes the literature on various metalloproteinases in testicular tissue physiology and pathology to elucidate their role in reproductive function and male reproductive mechanisms.

Keywords: ADAM; ADAMTS; ECM; MMP; Spermatogenesis; Testis.