Osteoimmunomodulatory Nanoparticles for Bone Regeneration

Jingyi Wen; Donglin Cai; Wendong Gao; Ruiying He; Yulin Li; Yinghong Zhou; Travis Klein; Lan Xiao; Yin Xiao

doi:10.3390/nano13040692

Osteoimmunomodulatory Nanoparticles for Bone Regeneration

Nanomaterials (Basel). 2023 Feb 10;13(4):692. doi: 10.3390/nano13040692.

Authors

Jingyi Wen¹, Donglin Cai², Wendong Gao¹, Ruiying He³, Yulin Li⁴, Yinghong Zhou^{5

6}, Travis Klein^{1

6}, Lan Xiao^{1

6}, Yin Xiao^{1

2

6}

Affiliations

¹ School of Mechanical, Medical and Process Engineering, Centre for Biomedical Technologies, Queensland University of Technology, Brisbane, QLD 4059, Australia.
² School of Medicine and Dentistry, Menzies Health Institute Queensland, Griffith University, Southport, QLD 4222, Australia.
³ College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430061, China.
⁴ The Key Laboratory for Ultrafine Materials of Ministry of Education, State Key Laboratory of Bioreactor Engineering, Engineering Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200231, China.
⁵ School of Dentistry, The University of Queensland, Herston, QLD 4006, Australia.
⁶ Australia-China Centre for Tissue Engineering and Regenerative Medicine, Queensland University of Technology, Brisbane, QLD 4000, Australia.

Abstract

Treatment of large bone fractures remains a challenge for orthopedists. Bone regeneration is a complex process that includes skeletal cells such as osteoblasts, osteoclasts, and immune cells to regulate bone formation and resorption. Osteoimmunology, studying this complicated process, has recently been used to develop biomaterials for advanced bone regeneration. Ideally, a biomaterial shall enable a timely switch from early stage inflammatory (to recruit osteogenic progenitor cells) to later-stage anti-inflammatory (to promote differentiation and terminal osteogenic mineralization and model the microstructure of bone tissue) in immune cells, especially the M1-to-M2 phenotype switch in macrophage populations, for bone regeneration. Nanoparticle (NP)-based advanced drug delivery systems can enable the controlled release of therapeutic reagents and the delivery of therapeutics into specific cell types, thereby benefiting bone regeneration through osteoimmunomodulation. In this review, we briefly describe the significance of osteoimmunology in bone regeneration, the advancement of NP-based approaches for bone regeneration, and the application of NPs in macrophage-targeting drug delivery for advanced osteoimmunomodulation.

Keywords: bone regeneration; nanomedicine; nanoparticles; osteoimmunomodulation; targeted drug delivery.

Publication types

Review

Grants and funding

This research was supported by the Joint Research Centre Fund from the Department of Environment and Science (2019–2023), Queensland; Young Researcher Grant (19-066) from the Osteology Foundation, Switzerland, QUT Centre for Biomedical Technologies ECR/MCR grant scheme 2021.