Osteoma of the Jaw as First Clinical Sign of Gardner's Syndrome: The Experience of Two Italian Centers and Review

Silvia D'Agostino; Fabio Dell'Olio; Angela Tempesta; Francesca Cervinara; Antonio D'Amati; Marco Dolci; Gianfranco Favia; Saverio Capodiferro; Luisa Limongelli

doi:10.3390/jcm12041496

Osteoma of the Jaw as First Clinical Sign of Gardner's Syndrome: The Experience of Two Italian Centers and Review

J Clin Med. 2023 Feb 14;12(4):1496. doi: 10.3390/jcm12041496.

Authors

Silvia D'Agostino¹, Fabio Dell'Olio², Angela Tempesta², Francesca Cervinara², Antonio D'Amati³, Marco Dolci¹, Gianfranco Favia², Saverio Capodiferro², Luisa Limongelli²

Affiliations

¹ Department of Medical, Oral, and Biotechnological Sciences, University G. d'Annunzio, 66100 Chieti, Italy.
² Complex Operating Unit of Odontostomatology, Department of Interdisciplinary Medicine, Aldo Moro University, 70121 Bari, Italy.
³ Operating Unit of Pathological Anatomy, Department of Emergency and Organ Transplantation, Aldo Moro University, 70121 Bari, Italy.

Abstract

Gardner's syndrome (GS) is a combination of polyposis, osteomas, fibromas, and sebaceous cysts. The aim of the study is to highlight whether maxillofacial osteoma could represent an early detection symptom of GS. Patients with suspected osteoma of the jaw underwent genetic and radiographical examinations. The database gathered 19 patients with oral osteoma that was histologically diagnosed; the whole sample was positive for APC gene mutation. Other cranial and peripheral locations were reported. Osteoma of the jaw is a crucial predictive factor of GS, and dentists and oral and maxillofacial surgeons must be aware of the importance of a timely diagnosis.

Keywords: Gardner’s syndrome; desmoid tumors; familial adenomatous polyposis; osteomas; supernumerary teeth.

Grants and funding

This research received no external funding.