Risk and Protective Factors for Frailty in Pre-Frail and Frail Older Adults

Int J Environ Res Public Health. 2023 Feb 10;20(4):3123. doi: 10.3390/ijerph20043123.

Abstract

This study aims to evaluate the differences in body composition, physical function, and physical activity between pre-frail/frail older adults and to detect risk and protective factors against frailty and physical frailty. Fried's criteria for frailty and physical frailty using the short-performance physical battery (SPPB) were measured in 179 older participants (75.3 ± 6.4 years old). Body weight, height, and waist, arm, and leg circumferences were obtained as body composition variables. Daily accelerometer outcomes (physical activity and inactivity) were obtained. Pre-frail participants showed overall better physical function and spent more time in physical activity and less time in long inactivity periods than frail participants (p < 0.05). Risk frailty factors were higher waist perimeter (Odds Ratio [OR]: 1.032, 95%CI: 1.003-1.062), low leg performance (OR: 1.025, 95%CI: 1.008-1.043), and inactivity periods longer than 30 min (OR:1.002, 95%CI: 1.000-1.005). Protective factors were standing balance (OR:0.908, 95%CI: 0.831-0.992) and SPPB score (OR: 0.908, 95%CI: 0.831-0.992) for frailty, handgrip strength (OR: 0.902, 95%CI: 0.844-0.964) for physical frailty, and light (OR: 0.986, 95%CI: 0.976-0.996) and moderate-to-vigorous (OR: 0.983, 95%CI: 0.972-0.996) physical activity for both. Our findings suggest that handgrip strength, balance, and physical activity are protective frailty factors and can be monitored in pre-frail older adults. Moreover, poor lower body performance and long inactivity periods are frailty risk factors, which highlights their importance in frailty assessment.

Keywords: accelerometry; ageing; dependency; physical activity; physical function; strength.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Body Weight
  • Frail Elderly*
  • Frailty* / diagnosis
  • Geriatric Assessment
  • Hand Strength
  • Humans
  • Protective Factors

Grants and funding

This study (project UMA20-FEDERJA-154) has been funding by 10.13039/501100011011 Junta de Andalucía and ERDF in the framework of the projects ERDF-Andalusia Operational Programme 2014–2020 (Programa Operativo FEDER Andalucía 2014–2020). J.C.-P. is supported by a predoctoral grant from the Spanish Ministry of Education (Ministerio de Educación), grant number FPU19/02326. L.Á.-C.d.V. and A.G.-M. are supported by a research collaboration grant from the Spanish Ministry of Education and Vocational Training (Ministerio de Educación y Formación Profesional) (grant number 22CO1/012259 and 22CO1/009662, respectively).