Lnc-uc.147 Is Associated with Disease Stage of Liver, Gastric, and Renal Cancer

Biomolecules. 2023 Jan 31;13(2):265. doi: 10.3390/biom13020265.

Abstract

Lnc-uc.147, a long non-coding RNA derived from a transcribed ultraconserved region (T-UCR), was previously evidenced in breast cancer. However, the role of this region in other tumor types was not previously investigated. The present study aimed to investigate lnc-uc.147 in different types of cancer, as well as to suggest lnc-uc.147 functional and regulation aspects. From solid tumor datasets analysis of The Cancer Genome Atlas (TCGA), deregulated lnc-uc.147 expression was associated with the histologic grade of hepatocellular carcinoma, and with the tumor stage of clear cell renal and gastric adenocarcinoma. Considering the epidemiologic relevance of liver cancer, silencing lnc-uc.147 reduced the viability and clonogenic capacity of HepG2 cell lines. Additionally, we suggest a relation between the transcription factor TEAD4 and lnc-uc.147 in liver and breast cancer cells.

Keywords: T-UCRs; TEA domain transcription factor 4; liver cancer; lnc-uc.147; lncRNAs; uc.147.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Breast Neoplasms* / genetics
  • Carcinoma, Hepatocellular* / genetics
  • Carcinoma, Renal Cell* / genetics
  • Conserved Sequence / genetics
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Kidney Neoplasms* / genetics
  • RNA, Long Noncoding* / genetics
  • TEA Domain Transcription Factors

Substances

  • RNA, Long Noncoding
  • TEAD4 protein, human
  • TEA Domain Transcription Factors

Grants and funding

This work was supported by the MD Anderson Cancer Center, CNPq, CAPES, and PRPPG/UFPR (23075.044468/2021-71).