Neuropilin 1-targeted near-infrared fluorescence probes for tumor diagnosis

Shuai Qin; Qingzhu Liu; Ke Li; Ling Qiu; Minhao Xie; Jianguo Lin

doi:10.1016/j.bmcl.2023.129196

Neuropilin 1-targeted near-infrared fluorescence probes for tumor diagnosis

Bioorg Med Chem Lett. 2023 Mar 15:84:129196. doi: 10.1016/j.bmcl.2023.129196. Epub 2023 Feb 23.

Authors

Shuai Qin¹, Qingzhu Liu², Ke Li², Ling Qiu², Minhao Xie³, Jianguo Lin⁴

Affiliations

¹ School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China; NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China.
² NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China.
³ School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China; NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China. Electronic address: xieminhao@jsinm.org.
⁴ NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China. Electronic address: linjianguo@jsinm.org.

PMID: 36828298
DOI: 10.1016/j.bmcl.2023.129196

Abstract

Two neuropilin 1 (NRP1)-targeted near-infrared fluorescence probes for tumor imaging were synthesized via click reaction. These two probes achieve excellent solubility and less aggregation. Importantly, they were able to rapidly target NRP1-overexpressing tumors and had long retention within tumors. Additionally, QS-1 with appropriate hydrophilicity displays higher tumor to muscle (T/M) ratio. And QS-1 can be easily modified with other functional group, and serve as a platform for constructing dual-modal or dual-targeting probes.

Keywords: Cyanine dye; Near infrared fluorescence imaging; Neuropilin 1 (NRP1); Tumor targeting.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Fluorescent Dyes*
Neuropilin-1*
Optical Imaging

Substances

Fluorescent Dyes
Neuropilin-1