Chemical modification strategies to prepare advanced protein-based biomaterials

Maria C Gomes; João F Mano

doi:10.1016/j.bbiosy.2021.100010

Chemical modification strategies to prepare advanced protein-based biomaterials

Biomater Biosyst. 2021 Feb 5:1:100010. doi: 10.1016/j.bbiosy.2021.100010. eCollection 2021 Mar.

Authors

Maria C Gomes¹, João F Mano¹

Affiliation

¹ Department of Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal.

Abstract

Nature is a superb source of inspiration when it comes to the development of biomaterials. Proteins, an exquisite asset virtually involved in all biological functions, are envisioned as a biomaterial due to their ability to be chemically modified. Owing to the rich chemical repertoire provided by the side chains and C-/N-terminus present in their backbone, scientists are pursuing chemical ways to upgrade isolated proteins, while maintaining their biological activity or relevant structural properties. By inserting chemical motifs, the crosslinking capability of proteins and capability to attach biochemical and molecular groups can be controlled yielding nano to macro constructs and hydrogels with improved physicochemical and mechanical properties. These cutting-edge approaches elevate the potential use of proteins as promising biomaterials for biotechnology and biomedicine.