Lipid transfer protein syndrome in a Northern European patient: An unusual case report

E Albert; T Walsemann; J Behrends; U Jappe

doi:10.3389/fmed.2023.1049477

Lipid transfer protein syndrome in a Northern European patient: An unusual case report

Front Med (Lausanne). 2023 Feb 7:10:1049477. doi: 10.3389/fmed.2023.1049477. eCollection 2023.

Authors

E Albert¹, T Walsemann¹, J Behrends², U Jappe^{1

3}

Affiliations

¹ Division of Clinical and Molecular Allergology, Research Center Borstel, Leibniz Lung Center, Airway Research Center North (ARCN), Member of the German Center for Lung Research, Borstel, Germany.
² Core Facility Fluorescence Cytometry, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.
³ Interdisciplinary Allergy Outpatient Clinic, Medical Clinic III - Pneumology, University of Lübeck, Lübeck, Germany.

Abstract

Non-specific lipid transfer proteins (nsLTPs) as the primary sensitizer in plant-food allergic patients used to be seen primarily in the Mediterranean area. However, more recently, increasing numbers of clinically relevant sensitizations are being observed in Northern Europe. We herein report an unusual case of a woman who developed an anaphylactic reaction during a meal including a variety of different foods ranging from fruits and nuts to oats, wheat, and salmon. Allergy diagnostics showed no Bet v 1 sensitization but an nsLTP-mediated food allergy. Despite the much more prominent birch food syndrome in Central and Northern Europe, LTPs should be considered disease-causing agents, especially for patients developing severe reactions after consuming LTP-containing foods.

Keywords: LTP; LTP syndrome; basophil activation test; exercise-induced anaphylaxis; food allergy; non-specific lipid transfer protein.

Publication types

Case Reports