Multicentric reticulohistiocytosis with eosinophilic gastroenteritis: An unusual relationship

Int J Rheum Dis. 2023 Jul;26(7):1377-1380. doi: 10.1111/1756-185X.14625. Epub 2023 Feb 23.

Abstract

Multicentric reticulohistiocytosis (MRH) is a rare disease with poorly defined therapeutic strategies. Here, we report the case of a patient with eosinophilic gastroenteritis who developed MRH after 5 years. The patient presented with disabling and rapidly progressive polyarthralgia, eosinophilic gastroenteritis, and resistance to first-line therapies. However, there was a marked improvement in the arthritis symptoms following treatment with tofacitinib. This presentation provides a useful perspective for the therapeutic management of complex scenarios involving MRH.

Keywords: eosinophilic gastroenteritis; multicentric reticulohistiocytosis; tofacitinib.

Publication types

  • Case Reports

MeSH terms

  • Arthritis* / diagnosis
  • Enteritis*
  • Eosinophilia* / complications
  • Eosinophilia* / diagnosis
  • Eosinophilia* / drug therapy
  • Histiocytosis, Non-Langerhans-Cell* / diagnosis
  • Histiocytosis, Non-Langerhans-Cell* / drug therapy
  • Humans

Supplementary concepts

  • Eosinophilic enteropathy