Protecting the kidney in sepsis: resident macrophages to the rescue

Kevin D Burns; Adrianna Douvris

doi:10.1016/j.kint.2022.11.012

Protecting the kidney in sepsis: resident macrophages to the rescue

Kidney Int. 2023 Mar;103(3):461-463. doi: 10.1016/j.kint.2022.11.012.

Authors

Kevin D Burns¹, Adrianna Douvris²

Affiliations

¹ Division of Nephrology, Department of Medicine, Kidney Research Centre, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada. Electronic address: kburns@toh.ca.
² Division of Nephrology, Department of Medicine, Kidney Research Centre, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.

PMID: 36822750
DOI: 10.1016/j.kint.2022.11.012

Abstract

Kidney resident macrophages exert pro-inflammatory or reparative effects in experimental acute kidney injury, but their role in sepsis is unclear. In a mouse model of sepsis, Privratsky et al. show that kidney resident F4/80^hi macrophages protect against kidney injury by expressing interleukin-1 receptor antagonist, which blocks interleukin-6 production selectively from endothelial cells. Discovery of this novel autocrine loop enhances opportunities for targeted therapies to diminish kidney injury during sepsis.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Acute Kidney Injury*
Animals
Endothelial Cells
Kidney
Macrophages
Mice
Sepsis*

Grants and funding

#388364/CIHR/Canada