Specific nanoarchitecture of silica nanoparticles codoped with the oppositely charged Mn2+ and Ru2+ complexes for dual paramagnetic-luminescent contrasting effects

Svetlana Fedorenko; Alexey Stepanov; Olga Bochkova; Kirill Kholin; Irek Nizameev; Alexandra Voloshina; Oksana Tyapkina; Dmitry Samigullin; Sofiya Kleshnina; Bulat Akhmadeev; Alexander Romashchenko; Evgenii Zavjalov; Rustem Amirov; Asiya Mustafina

doi:10.1016/j.nano.2023.102665

Specific nanoarchitecture of silica nanoparticles codoped with the oppositely charged Mn²⁺ and Ru²⁺ complexes for dual paramagnetic-luminescent contrasting effects

Nanomedicine. 2023 Apr:49:102665. doi: 10.1016/j.nano.2023.102665. Epub 2023 Feb 22.

Affiliations

¹ Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str., 8, 420088 Kazan, Russia. Electronic address: svetlana.fedorenko@yahoo.com.
² Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str., 8, 420088 Kazan, Russia.
³ Kazan National Research Technological University, 68, K. Marx str., 420015 Kazan, Russia.
⁴ Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center of RAS, 2/31 Lobachevski str., 420111 Kazan, Russia.
⁵ Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center of RAS, 2/31 Lobachevski str., 420111 Kazan, Russia; Kazan National Research Technical University named after A.N. Tupolev - KAI, 10 K. Marx str., 420111 Kazan, Russia.
⁶ Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation.
⁷ Kazan (Volga region) Federal University, 18 Kremlyovskaya str., 420008 Kazan, Russia.

PMID: 36822334
DOI: 10.1016/j.nano.2023.102665

Abstract

The silica nanoparticles (SNs) co-doped with paramagnetic ([Mn(HL)]^n-,) and luminescent ([Ru(dipy)₃]²⁺) complexes are represented. The specific distribution of [Mn(HL)]^n- within the SNs allows to achieve about ten-fold enhancing in magnetic relaxivities in comparison with those of [Mn(HL)]^n- in solutions. The leaching of [Mn(HL)]^n- from the shell can be minimized through the co-doping of [Ru(dipy)₃]²⁺ into the core of the SNs. The co-doped SNs exhibit colloid stability in aqueous solutions, including those modeling a blood serum. The surface of the co-doped SNs was also decorated by amino- and carboxy-groups. The cytotoxicity, hemoagglutination and hemolytic activities of the co-doped SNs are on the levels convenient for "in vivo" studies, although the amino-decorated SNs cause more noticeable agglutination and suppression of cell viability. The co-doped SNs being intravenously injected into mice allows to reveal their biodistribution in both ex vivo and in vivo conditions through confocal microscopy and magnetic resonance imaging correspondingly.

Keywords: Contrast agents; Ex vivo biodistribution; Manganese complexes; Relaxivity; Silica nanoparticles.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Contrast Media
Magnetic Resonance Imaging / methods
Mice
Nanoparticles*
Silicon Dioxide*
Tissue Distribution

Substances

Silicon Dioxide
Contrast Media