Neuromelanin magnetic resonance imaging of substantia nigra and locus coeruleus in Parkinson's disease with freezing of gait

Shangpei Wang; Tong Wu; Yajie Cai; Yongqiang Yu; Xianwen Chen; Longsheng Wang

doi:10.3389/fnagi.2023.1060935

Neuromelanin magnetic resonance imaging of substantia nigra and locus coeruleus in Parkinson's disease with freezing of gait

Front Aging Neurosci. 2023 Feb 2:15:1060935. doi: 10.3389/fnagi.2023.1060935. eCollection 2023.

Authors

Shangpei Wang¹, Tong Wu², Yajie Cai¹, Yongqiang Yu³, Xianwen Chen², Longsheng Wang¹

Affiliations

¹ Department of Radiology, The Second Hospital of Anhui Medical University, Hefei, Anhui, China.
² Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
³ Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

Abstract

Background: The downregulation of monoamines, especially dopamine in substantia nigra (SN) and norepinephrine in locus coeruleus (LC), may be responsible for freezing of gait (FOG) pathological basis in Parkinson's disease (PD).

Methods: Thirty-two Parkinson's disease patients with freezing of gait (PD-FOG), 32 Parkinson's disease patients without freezing of gait (PD-NFOG) and 32 healthy controls (HC) underwent neuromelanin magnetic resonance imaging (NM-MRI). The volume, surface area and contrast to noise ratio (CNR) of SN and LC were measured and compared. The correlation analyses were conducted between the measurements of SN and LC with clinical symptoms. We plotted the receiver operating characteristic (ROC) curve and determined the sensitivity and specificity of the CNR of SN and LC for discriminating the PD-FOG from the PD-NFOG.

Results: Both PD-FOG and PD-NFOG showed decreased volume, surface area and CNR of SN compared with HC. The PD-FOG exhibited decreased volume and surface area of LC compared with both PD-NFOG and HC groups, and decreased CNR of LC compared with HC group. The volume, surface area and CNR of SN were negatively correlated with the Unified Parkinson's Disease Rating Scale part III scores. The illness durations in PD patients were negatively correlated with the volume, surface area of SN, while not the CNR. And the volume and surface area of LC were negatively correlated with new freezing of gait questionnaire scores. ROC analyses indicated that the area under the curve (AUC) was 0.865 and 0.713 in the CNR of SN and LC, respectively, in PD versus HC, whereas it was 0.494 and 0.637 respectively, in PD-FOG versus PD-NFOG. Among these, for discriminating the PD from the HC, the sensitivity and specificity in the CNR of the SN was 90.6 and 71.9%, respectively, when the cut-off value was set at 2.101; the sensitivity and specificity in the CNR of the LC was 90.6 and 50.0%, respectively, when the cut-off value for CNR was set at 1.411.

Conclusion: The dopaminergic changes in the SN were found across both PD-FOG and PD-NFOG, whilst LC noradrenergic neuron reduction was more evident in PD-FOG.

Keywords: Parkinson’s disease; freezing of gait; locus coeruleus; neuromelanin MRI; substantia nigra.