Adiabatically prepared spin-lock could reduce the R1ρ dispersion

Abstract

Background: R_1ρ (or spin-lock) imaging is prone to artifacts arising from field inhomogeneities that may impact the R_1ρ quantification. Previous research has proposed two types of method to manage the artifacts in continuous-wave constant amplitude spin-lock, one is based on the composite block pulses to compensate for the field imperfections, another category uses adiabatic pulses in the R_1ρ pre-pulse to excite and reverse the magnetization (named adiabatic prepared approach). Although both methods have proved their efficiency in alleviating artifacts, we observed that the adiabatic pulse approach could produce much lower R_1ρ dispersion in human knee cartilage than the block pulse method (characterized by the R_1ρ difference ∆R_1ρ =11.4 Hz (from spin-lock field 50 to 500 Hz) for the block pulse method vs. ∆R_1ρ =4.5 Hz for the adiabatic pulse approach). Prompted by this observation, the purpose of this study was to investigate the underlying factors that may affect the R_1ρ dispersion through numerical simulations based on the two-pool exchanging Bloch-McConnell equations.

Methods: The effects of free water pool size P_a (from 0.80 to 0.95), chemical exchange rate k_b (from the bound to free water pool, ranged from 500 to 3,000 Hz), adiabatic pulse duration T_p (from 5.0 to 25 ms), and the chemical shift of the bound pool ppm_b (from 1.0 to 5.0 ppm) were examined on the degree of the R_1ρ dispersion for the two R_1ρ imaging methods.

Results: In general, the greater the ppm_b, k_b, T_p, and the smaller P_a, the more significant difference in R_1ρ dispersion between the block and adiabatic approaches, with the dispersion curve of the adiabatic method becoming flatter.

Conclusions: The adiabatic prepared approach may compromise the R_1ρ dispersion, the effect is determined by the combination of the tissue and radiofrequency (RF) pulse properties. It is suggested that care should be taken when using the adiabatically prepared approach to study R_1ρ dispersion.

Keywords: Bloch-McConnell equations; R1ρ dispersion; adiabatic pulse; chemical exchange.