Secondary metabolites from the Endophytic fungi Fusarium decemcellulare F25 and their antifungal activities

Ziwei Song; Yan Jun Sun; Shuangyu Xu; Gang Li; Chunmao Yuan; Kang Zhou

doi:10.3389/fmicb.2023.1127971

Secondary metabolites from the Endophytic fungi Fusarium decemcellulare F25 and their antifungal activities

Front Microbiol. 2023 Feb 1:14:1127971. doi: 10.3389/fmicb.2023.1127971. eCollection 2023.

Authors

Ziwei Song^{1

2}, Yan Jun Sun³, Shuangyu Xu⁴, Gang Li³, Chunmao Yuan⁴, Kang Zhou^{1

2}

Affiliations

¹ School of Pharmaceutical Sciences, Guizhou University, Guiyang, China.
² Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region, Ministry of Education, Guizhou University, Guiyang, China.
³ Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao, China.
⁴ State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, China.

Abstract

Seven new compounds, including three isocoumarins (1-3), three pyrrolidinone derivatives (8-10), and one pentaene diacid (15), together with 13 known compounds, were isolated from the rice culture of the endophytic fungus Fusarium decemcellulare F25. Their structures and stereochemistry were established using HRESIMS, NMR, electronic circular dichroism (ECD) calculations, and single-crystal X-ray diffraction. The possible biosynthetic pathways for compounds 1-3 and 8-10 were proposed. The antifungal efficacies of compounds 1 - 20 were evaluated against Colletotrichum musae, and compounds 13, 14, and 17 exhibited inhibitory activities against C. musae with MIC values of 256, 64 and 128 μg/mL, respectively.

Keywords: Fusarium decemcellulare F25; antifungal activities; isocoumarins; pyrrolidinones; secondary metabolites.