LncRNAs has been identified as regulators of Myeloid-derived suppressor cells in lung cancer

Yifan Liu; Yukun Han; Yanhua Zhang; Tongtong Lv; Xiaochun Peng; Jinbai Huang

doi:10.3389/fimmu.2023.1067520

LncRNAs has been identified as regulators of Myeloid-derived suppressor cells in lung cancer

Front Immunol. 2023 Feb 2:14:1067520. doi: 10.3389/fimmu.2023.1067520. eCollection 2023.

Authors

Yifan Liu^{1

2}, Yukun Han^{2

3}, Yanhua Zhang^{2

4}, Tongtong Lv^{2

4}, Xiaochun Peng^{2

4}, Jinbai Huang³

Affiliations

¹ Department of Oncology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei, China.
² Department of Pathophysiology, School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou, Hubei, China.
³ Department of Medical Imaging, School of Medicine, and Positron Emission Computed Tomography (PET) Center of the First Affiliated Hospital, Yangtze University, Jingzhou, Hubei, China.
⁴ Laboratory of Oncology, Center for Molecular Medicine, School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou, Hubei, China.

Abstract

Lung tumours are widespread pathological conditions that attract much attention due to their high incidence of death. The immune system contributes to the progression of these diseases, especially non-small cell lung cancer, resulting in the fast evolution of immune-targeted therapy. Myeloid-derived suppressor cells (MDSCs) have been suggested to promote the progression of cancer in the lungs by suppressing the immune response through various mechanisms. Herein, we summarized the clinical studies on lung cancer related to MDSCs. However, it is noteworthy to mention the discovery of long non-coding RNAs (lncRNAs) that had different phenotypes and could regulate MDSCs in lung cancer. Therefore, by reviewing the different phenotypes of lncRNAs and their regulation on MDSCs, we summarized the lncRNAs' impact on the progression of lung tumours. Data highlight LncRNAs as anti-cancer agents. Hence, we aim to discuss their possibilities to inhibit tumour growth and trigger the development of immunosuppressive factors such as MDSCs in lung cancer through the regulation of lncRNAs. The ultimate purpose is to propose novel and efficient therapy methods for curing patients with lung tumours.

Keywords: MDSC; immunotherapy; lncRNA; lung cancer; targeted therapy.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents*
Carcinoma, Non-Small-Cell Lung*
Humans
Lung Neoplasms*
Myeloid-Derived Suppressor Cells*
RNA, Long Noncoding* / genetics

Substances

RNA, Long Noncoding
Antineoplastic Agents

Grants and funding

This work was supported by National innovation and entrepreneurship training program for College Students (202010489017 to XP), Jingzhou Science and Technology Bureau Project (2022HC78 to XP), the College Students Innovative Entrepreneurial Training Program in Yangtze University (Yz2022297 to XP), the Scientific Research Project of Education Department of Yangtze university (JY2020134 to XP), Hubei Province Natural Science Foundation of China (2017CFB786 to XP).