Global scientific trends on matrix metalloproteinase and osteosarcoma: A bibliometric and visualized analysis

Xin Wu; Shiwei Ma; Zhongguang Wu; Qiangqiang Zhao

doi:10.3389/fonc.2023.1064815

Global scientific trends on matrix metalloproteinase and osteosarcoma: A bibliometric and visualized analysis

Front Oncol. 2023 Feb 6:13:1064815. doi: 10.3389/fonc.2023.1064815. eCollection 2023.

Authors

Xin Wu¹, Shiwei Ma², Zhongguang Wu³, Qiangqiang Zhao⁴

Affiliations

¹ Department of Spine Surgery, Third Xiangya Hospital, Central South University, Changsha, China.
² Department of Anesthesiology, Third Xiangya Hospital, Central South University, Changsha, China.
³ Department of Laboratory Medicine, Shenzhen University General Hospital, Shenzhen, China.
⁴ Department of Hematology, The Qinghai Provincial People's Hospital, Xining, China.

Abstract

Objective: This study aimed to identify author, country, institutional, and journal collaborations and their impacts, assess the knowledge base, identify existing trends, and uncover emerging topics related to the role of Metalloproteinase in osteosarcoma.

Methods: 945 Articles and reviews associated with the role of Metalloproteinase in osteosarcoma were obtained from the WoSCC and analyzed by Citespace and Vosviewer.

Results: The main aspects of research on the role of MMP in OS are invasion and metastasis. The latest hotspots were found to be the mechanism of MMP promoting invasion and metastasis, lung metastasis, and antitumor activity. Notably, invasion, metastasis, and antitumor activity were potentially turning points in the MMP-OS field. In the future, the primary research hotspot in the field of MMP-OS may be to study the mechanism, explore their role in the OS lung metastasis, and determine their role in the cancer therapy process.

Conclusion: This study thus offers a comprehensive overview of the MMP-OS-related field using bibliometrics and visual methods, which will provide a valuable reference for researchers interested in the field of MMP-OS.

Keywords: bibliometric; matrix metalloproteinase; osteosarcoma; prognoses; pulmonary metastasis.

Grants and funding

Central Universities of Central South University funded this research under Grant (No. 2020zzts896). This work was supported by grants from the Project of Kunlun Elite, High-End Innovation and Entrepreneurship Talents of Qinghai Province (2021 No. 13). The guiding project of Qinghai Provincial Health and Family Planning Commission (2018-wjzdx17). This work was supported by the National Natural Science Foundation of China (No. 82260365).