Possible association of fimA genotype of Porphyromonas gulae with the severity of periodontal disease and the number of permanent teeth in dogs

So Shirahata; Naoki Iwashita; Rie Sasaki; Ryota Nomura; Masaru Murakami; Junya Yasuda; Hidemi Yasuda; Kuniyasu Nakajima; Hiroaki Inaba; Michiyo Matsumoto-Nakano; Kazuhiko Nakano; Jumpei Uchiyama; Tomoki Fukuyama

doi:10.3389/fvets.2023.1022838

Possible association of fimA genotype of Porphyromonas gulae with the severity of periodontal disease and the number of permanent teeth in dogs

Front Vet Sci. 2023 Feb 6:10:1022838. doi: 10.3389/fvets.2023.1022838. eCollection 2023.

Authors

So Shirahata^{1

2}, Naoki Iwashita^{1

3}, Rie Sasaki¹, Ryota Nomura⁴, Masaru Murakami⁵, Junya Yasuda⁶, Hidemi Yasuda⁷, Kuniyasu Nakajima⁸, Hiroaki Inaba⁹, Michiyo Matsumoto-Nakano⁹, Kazuhiko Nakano⁴, Jumpei Uchiyama¹⁰, Tomoki Fukuyama¹

Affiliations

¹ Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, Japan.
² Primo Animal Hospital Sagamiharachuo, Sagamihara, Kanagawa, Japan.
³ Bioalchemis, Fuchu, Tokyo, Japan.
⁴ Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan.
⁵ Laboratory of Molecular Biology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, Japan.
⁶ SPECTRUM LAB. JAPAN Co., LTD., Yasuda Veterinary Clinic, Tokyo, Japan.
⁷ AlphaVets Co., LTD., Yasuda Veterinary Clinic, Tokyo, Japan.
⁸ Nakajima Animal Hospital, Tokyo, Japan.
⁹ Department of Pediatric Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
¹⁰ Department of Bacteriology, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Okayama, Japan.

Abstract

Previous research has demonstrated that Porphyromonas gulae (P. gulae) significantly contributes to the development of periodontal disease in dogs. Porphyromonas gulae is divided into three subtypes according to the 41-kDa filamentous appendage (fimA), defined as types A, B, and C. This study aimed to elucidate the association between fimA type of P. gulae with the number of permanent teeth, reflecting the severity of periodontal disease. Two hundred twenty-five dogs were categorized by P. gulae fimA type as negative, type A dominant, type B dominant, and type C dominant. The stage of periodontal disease in P. gulae-positive dogs increased with age, particularly in type C dominant dogs. Correspondingly, the number of permanent teeth in P. gulae fimA type C-dominant dogs was significantly lower than that of P. gulae-negative dogs, suggesting there is a significant association between fimA type of P. gulae and the number of permanent teeth resulting from the development of periodontal disease.

Keywords: Porphyromonas gulae; dog; fimA type; number of permanent teeth; periodontal disease.