Splenomegaly in Kawasaki Disease: A Pitfall in Diagnosis

Francesca Miselli; Maria Vincenza Mastrolia; Gabriele Simonini; Sandra Trapani; Giovanni Battista Calabri

doi:10.1016/j.jpeds.2023.02.006

Splenomegaly in Kawasaki Disease: A Pitfall in Diagnosis

J Pediatr. 2023 Jun:257:113359. doi: 10.1016/j.jpeds.2023.02.006. Epub 2023 Feb 21.

Authors

Francesca Miselli¹, Maria Vincenza Mastrolia², Gabriele Simonini³, Sandra Trapani⁴, Giovanni Battista Calabri⁵

Affiliations

¹ Department of Health Sciences, University of Florence, Florence, Italy.
² Rheumatology Unit, ERN ReCONNET Center, Meyer Children Hospital IRCCS, Florence, Italy.
³ Rheumatology Unit, ERN ReCONNET Center, Meyer Children Hospital IRCCS, Florence, Italy; NEUROFARBA Department, University of Florence, Florence, Italy.
⁴ Department of Health Sciences, Paediatric Section, Meyer Children Hospital IRCCS, Florence, Italy.
⁵ Paediatric Cardiology Unit, Meyer Children Hospital IRCCS, Florence, Italy. Electronic address: giovanni.calabri@meyer.it.

PMID: 36813130
DOI: 10.1016/j.jpeds.2023.02.006

Abstract

Among the 365 children diagnosed as having Kawasaki disease (KD), only 5 children (1.4%) presented with splenomegaly: 2 complicated by macrophage activation syndrome and 3 ultimately received a diagnosis of alternative systemic illness. Splenomegaly is atypical in KD and a potential marker of an underling complication, namely macrophage activation syndrome, or diagnosis other than KD.

Keywords: differential diagnosis; macrophage activation syndrome.

Publication types

Case Reports

MeSH terms

Child
Humans
Macrophage Activation Syndrome* / diagnosis
Mucocutaneous Lymph Node Syndrome* / complications
Mucocutaneous Lymph Node Syndrome* / diagnosis
Splenomegaly / complications