Advances in the study of aerobic glycolytic effects in resistance to radiotherapy in malignant tumors

Yuyi Liu; Zhengfu Feng; Pingmei Zhang; Honghao Chen; Song Zhu; Xin Wang

doi:10.7717/peerj.14930

Advances in the study of aerobic glycolytic effects in resistance to radiotherapy in malignant tumors

PeerJ. 2023 Feb 16:11:e14930. doi: 10.7717/peerj.14930. eCollection 2023.

Authors

Yuyi Liu¹, Zhengfu Feng¹, Pingmei Zhang¹, Honghao Chen¹, Song Zhu¹, Xin Wang¹

Affiliation

¹ Department of Radiotherapy, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan, China.

Abstract

Aerobic glycolysis is a metabolic mode of tumor cells different from normal cells that plays an important role in tumor proliferation and distant metastasis. Radiotherapy has now become a routine and effective treatment for many malignancies, however, resistance to radiotherapy remains a major challenge in the treatment of malignant tumors. Recent studies have found that the abnormal activity of the aerobic glycolysis process in tumor cells is most likely involved in regulating chemoresistance and radiation therapy resistance in malignant tumors. However, research on the functions and mechanisms of aerobic glycolysis in the molecular mechanisms of resistance to radiotherapy in malignant tumors is still in its early stages. This review collects recent studies on the effects of aerobic glycolysis and radiation therapy resistance in malignant tumors, to further understand the progress in this area. This research may more effectively guide the clinical development of more powerful treatment plans for radiation therapy resistant subtypes of cancer patients, and take an important step to improve the disease control rate of radiation therapy resistant subtypes of cancer patients.

Keywords: Aerobic glycolysis; Cancer; Metabolic reprogramming; Radioresistance.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Glycolysis
Humans
Neoplasms* / radiotherapy
Radiation Tolerance*

Grants and funding

This work was supported by the National Natural Science Foundation of China (grant no. 82002920), the Guangzhou Education Bureau University Scientific Research Project (grant no. 202032825), the Medical Science and Technology Research Foundation of Guangdong Province (grant no. B2018217). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.