Biallelic MGMT loss in a case of IDH-wild-type adult glioblastoma: a case for concurrent epigenomic and molecular karyotype testing

Pathology. 2023 Jun;55(4):551-554. doi: 10.1016/j.pathol.2022.10.015. Epub 2023 Jan 20.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adult
  • Brain Neoplasms* / diagnosis
  • Brain Neoplasms* / genetics
  • DNA Methylation
  • DNA Modification Methylases / genetics
  • DNA Modification Methylases / metabolism
  • DNA Repair Enzymes / genetics
  • DNA Repair Enzymes / metabolism
  • Epigenomics
  • Glioblastoma* / diagnosis
  • Glioblastoma* / genetics
  • Humans
  • Isocitrate Dehydrogenase / genetics
  • Karyotype
  • Mutation
  • Prognosis
  • Tumor Suppressor Proteins / genetics

Substances

  • Tumor Suppressor Proteins
  • Isocitrate Dehydrogenase
  • DNA Repair Enzymes
  • MGMT protein, human
  • DNA Modification Methylases