The Use of a Dehydrated Complete Human Placental Membrane Allograft for Mohs Surgical Defects of the Nose

Dermatol Surg. 2023 Apr 1;49(4):343-347. doi: 10.1097/DSS.0000000000003711. Epub 2023 Feb 13.

Abstract

Background: Repair options for Mohs surgical defects include primary closure, flap or graft, or healing by second intention. These options may not be optimal in all cases. A dehydrated complete human placental membrane (dCHPM) allograft may serve as an alternative repair option.

Objective: To assess the aesthetic and functional outcomes of an alternative repair technique for Mohs surgical defects of the nose.

Methods: Twenty patients with Mohs surgical defects of the nose repaired with a dCHPM allograft were retrospectively identified. Photographs were used to demonstrate surgical technique and outcomes. Two blinded observers evaluated final outcomes using the Patient and Observer Scar Assessment Scale.

Results: Observers rated the scar outcome a combined mean score of 8.4 ± 3.2 (scale 5-50). Patients rated their outcomes a mean of 12.6 ± 7.4 (scale 6-60). The mean "Overall Opinion score" was 2.5 ± 1.8 by patients and 1.9 ± 1.3 by observers (scale 1-10).

Limitations: This was a single institution study with a small sample size.

Conclusion: Our study demonstrates that dCHPM allografts are a viable alternative repair option for Mohs surgical defects of the nose.

MeSH terms

  • Allografts
  • Cicatrix* / surgery
  • Female
  • Humans
  • Mohs Surgery
  • Nose / pathology
  • Nose / surgery
  • Nose Neoplasms* / surgery
  • Placenta / surgery
  • Pregnancy
  • Retrospective Studies