Jiangchuanmycin, a New Pyrrolizidine Analog from Streptomyces sp. YIM S01863

Yuan Xu; Bin-Yuan Hu; Yan Qin; Lu Zhuang; Ya-Bin Yang; Li-Xing Zhao

doi:10.1002/cbdv.202201240

Jiangchuanmycin, a New Pyrrolizidine Analog from Streptomyces sp. YIM S01863

Chem Biodivers. 2023 Mar;20(3):e202201240. doi: 10.1002/cbdv.202201240. Epub 2023 Mar 3.

Authors

Yuan Xu¹, Bin-Yuan Hu¹, Yan Qin¹, Lu Zhuang¹, Ya-Bin Yang², Li-Xing Zhao^{1

3}

Affiliations

¹ Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, Yunnan Characteristic Plant Extraction Laboratory, School of Chemical Science and Technology, Yunnan University, Kunming, 650500, P. R. China.
² Key Laboratory of Functional Molecules Analysis and Biotransformation of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, P. R. China.
³ Yunnan Institute of Microbiology, Yunnan University, Kunming, 650091, P. R. China.

PMID: 36799244
DOI: 10.1002/cbdv.202201240

Abstract

Jiangchuanmycin (1), a new indole containing pyrrolizidine, and six known peptides (2-7) were obtained from the fermentation broth of a Streptomyces isolate collected from a sediment sample of Xingyun Lake, Jiangchuan, China. Their structures were elucidated on the detailed analysis of the HR-ESI-MS, 1D and 2D NMR, ECD, and X-ray crystallographic data. Jiangchuanmycin (1) presented weak inhibitory effects on cell lines of H1299, MHCC97H, HCT116 with the IC₅₀ values of 97.6 μM, 98.6 μM and 40.6 μM, respectively.

Keywords: Streptomyces; actinomycetes; antitumor activity; indole; pyrrolizidine.

MeSH terms

Antineoplastic Agents* / chemistry
Antineoplastic Agents* / pharmacology
Cell Line, Tumor
Magnetic Resonance Spectroscopy
Molecular Structure
Streptomyces* / chemistry

Substances

Antineoplastic Agents

Abstract

MeSH terms

Substances

Grants and funding