Mitochondrial quality control and its role in osteoporosis

Chunlu Yan; Yao Shi; Lingqing Yuan; Donghui Lv; Bai Sun; Jiayu Wang; Xiyan Liu; Fangyu An

doi:10.3389/fendo.2023.1077058

Mitochondrial quality control and its role in osteoporosis

Front Endocrinol (Lausanne). 2023 Jan 30:14:1077058. doi: 10.3389/fendo.2023.1077058. eCollection 2023.

Authors

Chunlu Yan^{1

2}, Yao Shi³, Lingqing Yuan³, Donghui Lv¹, Bai Sun¹, Jiayu Wang¹, Xiyan Liu⁴, Fangyu An⁵

Affiliations

¹ School of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, China.
² Research Center of Traditional Chinese Medicine of Gansu, Gansu University of Chinese Medicine, Lanzhou, Gansu, China.
³ School of Basic Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, China.
⁴ Internal Medicine, Northwestern University, Xian, Shanxi, China.
⁵ Teaching Experiment Training Center, Gansu University of Chinese Medicine, Lanzhou, Gansu, China.

Abstract

Mitochondria are important organelles that provide cellular energy and play a vital role in cell differentiation and apoptosis. Osteoporosis is a chronic metabolic bone disease mainly caused by an imbalance in osteoblast and osteoclast activity. Under physiological conditions, mitochondria regulate the balance between osteogenesis and osteoclast activity and maintain bone homeostasis. Under pathological conditions, mitochondrial dysfunction alters this balance; this disruption is important in the pathogenesis of osteoporosis. Because of the role of mitochondrial dysfunction in osteoporosis, mitochondrial function can be targeted therapeutically in osteoporosis-related diseases. This article reviews different aspects of the pathological mechanism of mitochondrial dysfunction in osteoporosis, including mitochondrial fusion and fission, mitochondrial biogenesis, and mitophagy, and highlights targeted therapy of mitochondria in osteoporosis (diabetes induced osteoporosis and postmenopausal osteoporosis) to provide novel targets and prevention strategies for the prevention and treatment of osteoporosis and other chronic bone diseases.

Keywords: mitochondrial autophagy; mitochondrial biogenesis; mitochondrial fusion and fission; osteoporosis; targeted therapy.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Mitochondria* / metabolism
Mitophagy
Osteoclasts / metabolism
Osteogenesis
Osteoporosis* / pathology

Grants and funding

This article was funded by the grants from the National Natural Science Foundation of China (82060872), Natural Science Program in Gansu Province (21JR11RA138) and the Project in Science and Technique Plans of Lanzhou City (2022-3-22).