New monoterpenoid indole alkaloids from the stems of Tabernaemontana bovina Lour (Apocynaceae)

Xue-Wei Yan; Si-Yu Du; Xiao-Tong Wang; Kong-Kai Zhu; Lei Fang

doi:10.1080/14786419.2023.2180503

New monoterpenoid indole alkaloids from the stems of Tabernaemontana bovina Lour (Apocynaceae)

Nat Prod Res. 2023 Feb 14:1-6. doi: 10.1080/14786419.2023.2180503. Online ahead of print.

Authors

Xue-Wei Yan^{1

2}, Si-Yu Du^{1

3}, Xiao-Tong Wang⁴, Kong-Kai Zhu¹, Lei Fang^{1

2}

Affiliations

¹ School of Biological Science and Technology, University of Jinan, Jinan, China.
² Key Laboratory of Natural Pharmaceutical Chemistry, Shandong University of Traditional Chinese Medicine, Jinan, China.
³ Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, China.
⁴ PingYi County Traditional Chinese Medicine, Linyi, China.

PMID: 36787196
DOI: 10.1080/14786419.2023.2180503

Abstract

Two new monoterpenoid indole alkaloids, named taberibogines E and F (1 and 2), together with three known ones (3-5) were isolated from the stems of Tabernaemontana bovina Lour (Apocynaceae). Their structures including absolute configurations were elucidated from a combination of NMR and HRESIMS data and NMR calculations as well as DP4+ probability analyses. Compounds 1 and 2 exhibited inhibitory effects on LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages.

Keywords: Apocynaceae; Tabernaemontana bovina Lour; anti-inflammatory activity; monoterpenoid indole alkaloids.