COVID19 Impairs Cardiac Function via Endothelial H19 and IL6 Signaling

Circ Res. 2023 Mar 3;132(5):648-651. doi: 10.1161/CIRCRESAHA.122.322166. Epub 2023 Feb 14.

Rio P Juni^{1

2}, Philippa G Phelp^{1

2}, Diewertje I Bink^{1

2}, Veerle Kremer^{1

2}, Anke S van Bergen^{1

2}, Pedro Espinosa Gonzalez^{1

2}, Karlijn B Rombouts^{3

2}, Karl J Harber^{4

5}, Daan A F Heister^{4

5}, Kak K Yeung^{3

2}, Jan Van den Bossche^{4

5}, Diederik W D Kuster^{1

2}; Amsterdam UMC COVID-19 Biobank Study Group; Paul A J Krijnen⁶, Hans W M Niessen⁶, Reinier A Boon^{1

2

7

8}

¹ Department of Physiology (R.P.J., P.G.P., D.I.B., V.K., A.S.v.B., P.E.G., D.W.D.K., R.A.B.), Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, the Netherlands.
² Amsterdam Cardiovascular Sciences, Microcirculation, the Netherlands (R.P.J., P.G.P., D.I.B., V.K., A.S.v.B., P.E.G., K.B.R., K.K.Y., D.W.D.K., R.A.B.).
³ Department of Vascular Surgery (K.B.R., K.K.Y.), Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, the Netherlands.
⁴ Department of Molecular Cell Biology and Immunology (K.J.H., D.A.F.H., J.V.d.B.), Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, the Netherlands.
⁵ Amsterdam Cardiovascular Sciences, Diabetes and Metabolism, the Netherlands (K.J.H., D.A.F.H., J.V.d.B.).
⁶ Department of Pathology (P.A.J.K., H.W.M.N.), Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, the Netherlands.
⁷ Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt am Main, Germany (R.A.B.).
⁸ German Centre for Cardiovascular Research, Partner Site Frankfurt Rhein/Main (R.A.B.).

No abstract available

Keywords: COVID-19; RNA, long noncoding; endothelial cells; interleukins; myocytes, cardiac.

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