Surface Modification of Liposomes Using Folic Acid

Mengran Guo; Zhongshan He; Xi He; Xiangrong Song

doi:10.1007/978-1-0716-2954-3_16

Surface Modification of Liposomes Using Folic Acid

Methods Mol Biol. 2023:2622:191-196. doi: 10.1007/978-1-0716-2954-3_16.

Authors

Mengran Guo¹, Zhongshan He¹, Xi He¹, Xiangrong Song²

Affiliations

¹ Department of Critical Care Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
² Department of Critical Care Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China. songxr@scu.edu.cn.

PMID: 36781761
DOI: 10.1007/978-1-0716-2954-3_16

Abstract

Liposomes are usually defined as spherically shaped microscopic vesicles that consist of one or more phospholipid bilayer membranes. They are widely used in drug delivery due to their biocompatibility, biodegradability, and stability. In recent years, a growing body of research shows that folic acid (FA)-modified liposomes can be targeted to deliver therapeutics to tumor and inflammation sites via receptor-mediated endocytosis between FA and folate receptor (FR). Taking this advantage, FA-modified liposomes are usually used in the targeted treatment of cancer, atherosclerosis, and arthrosis. In this chapter, we provided a classical thin-film hydration method to prepare FA-modified liposomes. We expect that our strategies would provide new opportunities for the development of FA-modified liposomes for research and clinical uses.

Keywords: FA-modified liposomes; Folic acid; Liposomes; Surface modification; Targeted drug delivery; Thin-film hydration method.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Drug Delivery Systems
Folic Acid
Humans
Liposomes*
Neoplasms*

Substances

Liposomes
Folic Acid