Solid Lipid Nanoparticles for Drug Delivery

Wei-Chung Luo; Xiuling Lu

doi:10.1007/978-1-0716-2954-3_12

Solid Lipid Nanoparticles for Drug Delivery

Methods Mol Biol. 2023:2622:139-146. doi: 10.1007/978-1-0716-2954-3_12.

Authors

Wei-Chung Luo¹, Xiuling Lu²

Affiliations

¹ School of Pharmacy, University of Connecticut, Storrs, CT, USA.
² School of Pharmacy, University of Connecticut, Storrs, CT, USA. xiuling.lu@uconn.edu.

PMID: 36781757
DOI: 10.1007/978-1-0716-2954-3_12

Abstract

Solid lipid nanoparticles are promising carriers that allow for the delivery of poorly water-soluble drugs and have the potential to achieve sustained drug release or targeted delivery to the site of interest. Here we describe the preparation of solid lipid nanoparticles by forming a microemulsion at an elevated temperature which, upon cooling, yields a suspension of solid nanoparticles. This nanotemplate engineering method is inexpensive, reproducible, and easy to scale up.

Keywords: Cancer treatment; Dexamethasone palmitate; Microemulsion; Solid lipid nanoparticles; Sustained release.

MeSH terms

Drug Carriers
Drug Delivery Systems
Lipids*
Liposomes
Nanoparticles*
Particle Size

Substances

Lipid Nanoparticles
Lipids
Liposomes
Drug Carriers