The aim of the study was to increase the effectiveness of surgical treatment of patients with pleural empyema complicated by the development of bronchopleural fistula due to the personification of the surgical approach to treatment. The cohort observation group consisted of 136 patients who were treated at the I. V. Davydovsky State Clinical Hospital No. 23 for pleural empyema complicated by bronchopleural fistula. The main group included patients in whom a biological stimulator of local tissue repair (BSRMT) was used to treat EP with BPS. The comparison group included patients who used the installation of a valvular broncho blocker for the treatment of EP with BPS. Results: the effectiveness of the use of fibrin glue ranged from 57.1% to 86.4%, depending on the etiology of the EP. The effectiveness of broncho location ranges from 80% to 84.2%. The greatest effectiveness was observed with the simultaneous use of fibrin glue and broncho blocking. The use of biological stimulants based on fibrinogen and growth factors may be effective in the treatment of various nosologies of the thoracic profile. Fibrin glue, obtained from its own blood plasma, has good adhesion indicators, is biologically inert, in addition, it has the property of stimulating repair, which is extremely important in the treatment of such pathology as bronchopleural fistulas. However, the issue of the use of fibrin glue and other sealants requires further study.