The Genetics of Postoperative Recurrence in Crohn Disease: A Systematic Review, Meta-analysis, and Framework for Future Work

Jerry T Dang; ThucNhi T Dang; Eytan Wine; Bryan Dicken; Karen Madsen; Michael Laffin

doi:10.1093/crocol/otaa094

The Genetics of Postoperative Recurrence in Crohn Disease: A Systematic Review, Meta-analysis, and Framework for Future Work

Crohns Colitis 360. 2021 Mar 17;3(2):otaa094. doi: 10.1093/crocol/otaa094. eCollection 2021 Apr.

Authors

Jerry T Dang¹, ThucNhi T Dang², Eytan Wine³, Bryan Dicken¹, Karen Madsen², Michael Laffin¹

Affiliations

¹ Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.
² Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
³ Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.

Abstract

Background: Recurrence following abdominal surgery in Crohn disease is over 50%. The impact of genetics on postoperative recurrence is not well defined.

Methods: A literature search was conducted where inclusion required an assessment, by genotype, of postoperative recurrence. The primary endpoint was odds of surgical recurrence.

Results: Twenty-eight studies identified a total of 6715 patients. Thirteen loci were identified as modifying the risk of recurrence. NOD2 was identified as a risk factor for recurrence by multiple works (cumulative odds ratio: 1.64, P = 0.003).

Conclusions: A NOD2 risk allele is associated with recurrence following surgery in Crohn disease. Progress in this area will require standardized reporting in future works.

Keywords: CARD15; Crohn disease; NOD2; genetics; inflammatory bowel disease; recurrence.