More of less: Novel multi-ome profiling of single human neurons

Huiwen Che; Bernard Thienpont

doi:10.1016/j.xgen.2022.100110

More of less: Novel multi-ome profiling of single human neurons

Cell Genom. 2022 Mar 9;2(3):100110. doi: 10.1016/j.xgen.2022.100110.

Authors

Huiwen Che^{1

2}, Bernard Thienpont^{1

2

3}

Affiliations

¹ Laboratory for Functional Epigenetics, Department of Human Genetics, KU Leuven, Leuven 3000, Belgium.
² Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.
³ KU Leuven Institute for Single Cell Omics (LISCO), KU Leuven, Leuven 3000, Belgium.

Abstract

Epigenetic modifications to DNA and chromatin interact to influence gene expression and cellular phenotypes, but defining these omics layers in complex tissues is a daunting task. In this issue of Cell Genomics, Luo et al. describe a novel single-cell multi-omic method, simultaneously profiling transcriptome, DNA methylome, and chromatin accessibility, to shed light on human neurons.

Publication types

News