Full, Partial, and Modified Permutations of the Mayo Score: Characterizing Clinical and Patient-Reported Outcomes in Ulcerative Colitis Patients

April N Naegeli; Theresa Hunter; Yan Dong; Ben Hoskin; Chloe Middleton-Dalby; James Hetherington; Diana Stefani-Hunyady; James B Canavan

doi:10.1093/crocol/otab007

Full, Partial, and Modified Permutations of the Mayo Score: Characterizing Clinical and Patient-Reported Outcomes in Ulcerative Colitis Patients

Crohns Colitis 360. 2021 Feb 23;3(1):otab007. doi: 10.1093/crocol/otab007. eCollection 2021 Jan.

Authors

April N Naegeli¹, Theresa Hunter¹, Yan Dong¹, Ben Hoskin², Chloe Middleton-Dalby², James Hetherington², Diana Stefani-Hunyady¹, James B Canavan¹

Affiliations

¹ Eli Lilly and Company, Indianapolis, Indiana, USA.
² Adelphi Real World, Adelphi Mill, Bollington, Macclesfield, Cheshire, UK.

Abstract

Background: Understanding ulcerative colitis disease activity assessed via the full, modified, or partial Mayo Score may help clinicians apply results from clinical trials to practice and facilitate interpretation of recent and older studies.

Methods: Mayo Score variables were assessed in a cross-sectional study of 2608 ulcerative colitis patients.

Results: Permutations of Mayo Scores were highly correlated, and models predicting the omitted variable from each permutation demonstrated significant agreement between predicted and observed values.

Conclusions: Partial/modified Mayo Scores may be used to predict endoscopic and Physician's Global Assessment scores, and serve as proxies for the full Mayo Score in clinical practice/trials.

Keywords: Mayo Disease Activity Score; partial Mayo Score; patient-reported outcome measures; real world; ulcerative colitis.