Mitochondria-associated endoplasmic reticulum membranes (MAMs): Possible therapeutic targets in heart failure

Yu Zhang; Jiayu Yao; Mingming Zhang; Yushan Wang; Xingjuan Shi

doi:10.3389/fcvm.2023.1083935

Mitochondria-associated endoplasmic reticulum membranes (MAMs): Possible therapeutic targets in heart failure

Front Cardiovasc Med. 2023 Jan 26:10:1083935. doi: 10.3389/fcvm.2023.1083935. eCollection 2023.

Authors

Yu Zhang¹, Jiayu Yao¹, Mingming Zhang¹, Yushan Wang¹, Xingjuan Shi¹

Affiliation

¹ Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, China.

Abstract

Mitochondria-associated endoplasmic reticulum membranes (MAMs) are formed by physical connections of the endoplasmic reticulum and mitochondria. Over the past decades, great breakthroughs have been made in the study of ER-mitochondria communications. It has been identified that MAM compartments are pivotal in regulating neurological function. Accumulating studies indicated that MAMs participate in the development of cardiovascular diseases. However, the specific role of MAMs in heart failure remains to be fully understood. In this article, we first summarize the structural and functional properties of MAM and MAM-associated proteins. We then focus on the roles of MAMs in myocardial infarction, cardiomyopathy and heart failure, and discuss the involvement of MAMs in disease progression and treatment. Elucidating these issues may provide important insights into therapeutic intervention of heart failure.

Keywords: cardiomyopathy; cardiovascular diseases; heart failure; mitochondria-associated membranes (MAMs); myocardial infarction.

Publication types

Review

Grants and funding

This work was supported by grants from the National Natural Science Foundation of China (82170370 and 81770381), the Natural Science Foundation of Jiangsu Province (BK20211165), and Zhishan Youth Scholar Program of SEU.