Combined epidemiology and genetic sequencing surveillance in the era of COVID-19 pandemic; Abu Dhabi experience, United Arab Emirates

Infect Genet Evol. 2023 Apr:109:105411. doi: 10.1016/j.meegid.2023.105411. Epub 2023 Feb 10.

Abstract

Background: United Arab Emirates, has reported the first case of COVID-19 in January 2020 and by October 2022, a total of 1 Million cases and 2348 deaths due to COVID-19 have been reported. The Abu Dhabi Public Health Center, has led a novel initiative to conduct a large scale genomic surveillance project. The aim of this surveillance project is to generate data to guide public health pandemic response decision making.

Methods: Samples mainly from the community, points of entry to the emirate and healthcare facilities were collected for surveillance using both targeted PCR and/or Genome sequence analysis. Sample criteria were defined and specific metadata were collected in parallel. Using the unique identifiers and through the available datasets, epidemiological and clinical data were integrated.

Results: A total of 385,191 sample undertake analysis (from January 2021 to October 2022) either genotyping and/or sequence analysis. The most frequently encountered lineages in the community and among severe cases were reported.

Conclusions: Genomic surveillance is a major tool essential for guiding public health measures throughout the pandemic.

Keywords: Genetic Sequencing; Genomic epidemiology; SARS-CoV-2; Surveillance applications; Surveillance program; Surveillance strategies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • COVID-19* / epidemiology
  • Humans
  • Pandemics
  • Public Health
  • United Arab Emirates / epidemiology