Synthesis of 1,4-Dialkoxynaphthalene-Based Imidazolium Salts and Their Cytotoxicity in Cancer Cell Lines

Haena Lee; Yejin Jeon; Hyejin Moon; Eunjoo H Lee; Tae Hoon Lee; Hakwon Kim

doi:10.3390/ijms24032713

Synthesis of 1,4-Dialkoxynaphthalene-Based Imidazolium Salts and Their Cytotoxicity in Cancer Cell Lines

Int J Mol Sci. 2023 Feb 1;24(3):2713. doi: 10.3390/ijms24032713.

Authors

Haena Lee¹, Yejin Jeon², Hyejin Moon¹, Eunjoo H Lee², Tae Hoon Lee¹, Hakwon Kim¹

Affiliations

¹ Department of Applied Chemistry, Global Center for Pharmaceutical Ingredient Materials, Kyung Hee University, Yongin 1732, Republic of Korea.
² Department of Gerontology, Graduate School of East-West Medicinal Science, Kyung Hee University, Yongin 17104, Republic of Korea.

Abstract

In this study, we designed and synthesized novel 1,4-dialkoxynaphthalene-2-alkyl imidazolium salt (IMS) derivatives containing both 1,4-dialkoxynaphthalene and imidazole, which are well known as pharmacophores. The cytotoxicities of these newly synthesized IMS derivatives were investigated in order to explore the possibility of using them to develop anticancer drugs. It was found that some of the new IMS derivatives showed good cytotoxic activities. In addition, an initial, qualitative structure-activity relationship is presented on the basis of observations of activity changes corresponding to structural changes.

Keywords: 1,4-dialkoxynaphthalne; CCD-18Co; HT-29; HepG2; cancer; cytotoxicity; imidazole.

MeSH terms

Antineoplastic Agents* / chemistry
Cell Line
Cell Line, Tumor
Drug Screening Assays, Antitumor
Molecular Structure
Neoplasms*
Salts / chemistry
Salts / pharmacology
Sodium Chloride
Structure-Activity Relationship

Substances

Salts
Antineoplastic Agents
Sodium Chloride

Grants and funding

2020(B04)/Gyeonggi province