Screening for SARS-COV-2 Using RT-qPCR in Patients with Hematologic Neoplasms Receiving Chemotherapy

Prague Med Rep. 2023;124(1):33-39. doi: 10.14712/23362936.2023.3.

Abstract

It has been recommended that patients with leukaemias and lymphomas undergo universal screening for SARS-COV-2 using RT-qPCR before each treatment on the grounds of their high risk of experiencing severe forms of COVID-19. This raises a conflict with different recommendations which prioritise testing symptomatic patients. We found that among 56 RT-qPCR obtained in asymptomatic patients with hematologic neoplasms before chemotherapy administration, 2 (3.5%) were positive. A negative result did not exclude SARS-COV-2 infection in 1 patient (1.8%). It is unclear what the benefit of screening for SARS-COV-2 using RT-qPCR in patients with hematologic neoplasms who receive chemotherapy is.

Keywords: Asymptomatic disease; COVID-19 testing; Chemotherapy; Hematologic neoplasms.

MeSH terms

  • COVID-19 Testing
  • COVID-19* / diagnosis
  • Hematologic Neoplasms* / diagnosis
  • Hematologic Neoplasms* / drug therapy
  • Hematologic Neoplasms* / genetics
  • Humans
  • Leukemia*
  • SARS-CoV-2
  • Sensitivity and Specificity