Small molecular host-guest doped materials exhibit superiority toward high-efficiency room-temperature phosphorescence (RTP) materials due to their structural design diversity and ease of preparation. Dynamic RTP materials display excellent characteristics, such as good reversibility, quick response, and tunable luminescence ability, making them applicable to various cutting-edge technologies. Herein, we summarize the advances in host-guest doped dynamic RTP materials that respond to external and internal stimuli and present some insights into the molecular design strategies and underlying mechanisms. Subsequently, specific viewpoints are described regarding this promising field for the development of dynamic RTP materials. This Perspective is highly beneficial for future intelligent applications of dynamic RTP systems.