Less than a quarter of U.S. infants meet the federal recommendation for exclusively breastfeeding to 6 months of age, necessitating access to safe and effective infant formula. The U.S. National Institutes of Health (NIH) and Food and Drug Administration (FDA) held a public Workshop titled “Exploring the Science Surrounding the Safe Use of Bioactive Ingredients in Infant Formula: Considerations for an Assessment Framework” on September 23rd and September 24th, 2021. Commentary from the NIH and FDA perspectives on the workshop topics is provided in this publication.