ApoB, non-HDL-C, and LDL-C Are More Prominent in Retinal Artery Occlusion Compared to Retinal Vein Occlusion

Ting Chen; Ying Li; Yuedan Wang; Xuejie Li; Yuwei Wan; Xuan Xiao

doi:10.1080/09273948.2023.2173245

ApoB, non-HDL-C, and LDL-C Are More Prominent in Retinal Artery Occlusion Compared to Retinal Vein Occlusion

Ocul Immunol Inflamm. 2023 Feb 9:1-7. doi: 10.1080/09273948.2023.2173245. Online ahead of print.

Authors

Ting Chen¹, Ying Li¹, Yuedan Wang¹, Xuejie Li¹, Yuwei Wan¹, Xuan Xiao¹

Affiliation

¹ Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.

PMID: 36758248
DOI: 10.1080/09273948.2023.2173245

Abstract

Purpose: To evaluate and compare the blood lipid profile in retinal artery occlusion (RAO) and retinal vein occlusion (RVO).

Methods: We included 82 RAO patients and 95 RVO patients in this retrospective case-control study. Controls were matched to RAO or RVO patients at a 1:1 ratio, respectively. Associated lipid variates were analyzed in multivariable logistic regression models.

Results: LDL-C (OR = 1.69), non-HDL-C (OR = 1.87), and ApoB (OR = 11.72) individually significantly increased the risk of RAO. ApoA1 was associated with RVO (OR = 0.02), and with 75.8% sensitivity and 67.4% specificity. TG (OR = 1.61), LDL-C (OR = 1.69), non-HDL-C (OR = 1.91), and ApoB (OR = 12.12) each significantly increased the risk of RAO when compared with RVO.

Conclusions: ApoB, non-HDL-C, and LDL-C may be potential biomarkers in RAO patients. Low ApoA1 is an independent risk factor for the development of RVO.

Keywords: Atherosclerosis; biomarkers; lipid profile; retinal artery occlusion; retinal vein occlusion.