A copper foam-based surface-enhanced Raman scattering substrate for glucose detection

Wang Peng; Zhihan Xu; Xiangting Jia; Qingxi Liao

doi:10.1186/s11671-023-03776-x

A copper foam-based surface-enhanced Raman scattering substrate for glucose detection

Discov Nano. 2023 Feb 9;18(1):7. doi: 10.1186/s11671-023-03776-x.

Authors

Wang Peng^{1

2

3

4}, Zhihan Xu⁵, Xiangting Jia⁵, Qingxi Liao^{6

7}

Affiliations

¹ College of Engineering, Huazhong Agricultural University, Wuhan, 430070, China. pengwang@mail.hzau.edu.cn.
² Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, 518000, China. pengwang@mail.hzau.edu.cn.
³ Shenzhen Institute of Nutrition and Health, Huazhong Agricultural University, Wuhan, 430070, China. pengwang@mail.hzau.edu.cn.
⁴ Key Laboratory of Agricultural Equipment in Mid-Lower Yangtze River, Ministry of Agriculture and Rural Affairs, Wuhan, 430070, China. pengwang@mail.hzau.edu.cn.
⁵ College of Engineering, Huazhong Agricultural University, Wuhan, 430070, China.
⁶ College of Engineering, Huazhong Agricultural University, Wuhan, 430070, China. liaoqx@mail.hzau.edu.cn.
⁷ Key Laboratory of Agricultural Equipment in Mid-Lower Yangtze River, Ministry of Agriculture and Rural Affairs, Wuhan, 430070, China. liaoqx@mail.hzau.edu.cn.

Abstract

Raman spectroscopy can quickly achieve non-destructive, qualitative and quantitative detection, and analysis the molecular structure of substances. Herein, a facile and low-cost method for preparation of highly sensitivity SERS substrates was implemented through the displacement reaction of copper foam immersed in AgNO₃ ethanol solution. Due to the 3D structure of copper film and homogenous displacement, the Ag-Cu substrate showed high performance SERS enhancement (1.25 × 10⁷), and the lowest detection concentration for R6G reached 10^-10 Mol/L. For glucose detection, mixed decanethiol (DT)/mercaptohexanol (MH) interlayer was used to enable glucose attach to the substrate surface, and the limit of detection reached to 1 uM/L. SERS substrate makes the Ag-Cu SERS substrate promising for biological applications.

Keywords: Copper foam; Glucose detection; Surface-enhanced Raman scattering.

Abstract

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