Salty Treg cells get out of balance

Iosif Papafragkos; Panayotis Verginis

doi:10.1016/j.cmet.2023.01.008

Salty Treg cells get out of balance

Cell Metab. 2023 Feb 7;35(2):228-230. doi: 10.1016/j.cmet.2023.01.008.

Authors

Iosif Papafragkos¹, Panayotis Verginis²

Affiliations

¹ Laboratory of Immune Regulation and Tolerance, Division of Basic Sciences, University of Crete Medical School, Heraklion 71003, Greece; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Heraklion 70013, Greece.
² Laboratory of Immune Regulation and Tolerance, Division of Basic Sciences, University of Crete Medical School, Heraklion 71003, Greece; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Heraklion 70013, Greece. Electronic address: pverginis@uoc.gr.

PMID: 36754015
DOI: 10.1016/j.cmet.2023.01.008

Abstract

Although metabolic rewiring of Treg cells constitutes a hallmark in autoimmune diseases, extrinsic and intrinsic mechanisms that imprint on this re-programming remain poorly understood. In this issue of Cell Metabolism, Côrte-Real and colleagues demonstrate that high salt exposure disturbs the mitochondrial respiration in Treg cells, promoting a pro-inflammatory phenotype, loss of function, and associated breakdown of self-tolerance.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Autoimmune Diseases*
Humans
Immune Tolerance
Self Tolerance / genetics
T-Lymphocytes, Regulatory*