Discovery of pentacyclic triterpenoid glycosides with anti-proliferative activities from Ardisialindleyana

Abstract

One new pentacyclic triterpenoid glycoside, ardisiapunine E (1), along with two known compounds were isolated from the root of Ardisia lindleyana D.Dietr. Their structures were elucidated by ¹H and ¹³C NMR, DEPT, HMBC, HSQC, ¹H-¹H COSY and NOESY spectroscopic analyses, ESI-MS, and literature. Compounds 1-3 exhibited obvious anti-proliferative activities against the HeLa cell line in a dose- and time-dependent manner by inducing G2/M phase arrest and apoptosis in vitro, both consisting of pentacyclic triterpenes and sugar. Hence, this study identified a new and two known pentacyclic triterpenoid glycosides promoting apoptosis as a potential anti-proliferative agent.

Keywords: Anti-proliferative activity; Apoptosis; Ardisia lindleyana; Glycoside; Triterpenoid.