Solid-state NMR studies of amyloids

Jing Liu; Xia-Lian Wu; Yu-Teng Zeng; Zhi-Heng Hu; Jun-Xia Lu

doi:10.1016/j.str.2023.01.005

Solid-state NMR studies of amyloids

Structure. 2023 Mar 2;31(3):230-243. doi: 10.1016/j.str.2023.01.005. Epub 2023 Feb 6.

Authors

Jing Liu¹, Xia-Lian Wu¹, Yu-Teng Zeng¹, Zhi-Heng Hu¹, Jun-Xia Lu²

Affiliations

¹ School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
² School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Electronic address: lujx@shanghaitech.edu.cn.

PMID: 36750098
DOI: 10.1016/j.str.2023.01.005

Abstract

Amyloids have special structural properties and are involved in many aspects of biological function. In particular, amyloids are the cause or hallmarks of a group of notorious and incurable neurodegenerative diseases. The extraordinary high molecular weight and aggregation states of amyloids have posed a challenge for researchers studying them. Solid-state NMR (SSNMR) has been extensively applied to study the structures and dynamics of amyloids for the past 20 or more years and brought us tremendous progress in understanding their structure and related diseases. These studies, at the same time, helped to push SSNMR technical developments in sensitivity and resolution. In this review, some interesting research studies and important technical developments are highlighted to give the reader an overview of the current state of this field.

Keywords: amyloids; functional amyloids; neurodegenerative diseases; phase separation; solid-state NMR.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Amyloid* / chemistry
Magnetic Resonance Spectroscopy

Substances

Amyloid