Recently, Zr- and Ti-based metal-organic frameworks (MOFs) have gathered increasing interest in the field of chemistry and materials science, not only for their ordered porous structure, large surface area, and high thermal and chemical stability, but also for their various potential applications. Particularly, the unique features of Zr- and Ti-based MOFs enable them to be a highly versatile platform for catalysis. Although much effort has been devoted to developing Zr- and Ti-based MOF materials, they still suffer from difficulties in targeted synthesis, especially for Ti-based MOFs. In this Feature Article, we discuss the evolution of Zr- and Ti-based MOFs, giving a brief overview of their synthesis and structures. Furthermore, the catalytic uses of Zr- and Ti-based MOF materials in the previous 3-5 years have been highlighted. Finally, perspectives on the Zr- and Ti-based MOF materials are also proposed. This work provides in-depth insight into the advances in Zr- and Ti-based MOFs and boosts their catalytic applications.