Chemical modification of β-cyclodextrin towards hydrogel formation

Arpita Roy; Kalipada Manna; Shaon Dey; Sagar Pal

doi:10.1016/j.carbpol.2023.120576

Chemical modification of β-cyclodextrin towards hydrogel formation

Carbohydr Polym. 2023 Apr 15:306:120576. doi: 10.1016/j.carbpol.2023.120576. Epub 2023 Jan 13.

Authors

Arpita Roy¹, Kalipada Manna², Shaon Dey², Sagar Pal³

Affiliations

¹ Department of Chemistry and Chemical Biology, Indian Institute of Technology (ISM) Dhanbad, Jharkhand 826004, India. Electronic address: arpitachem28@gmail.com.
² Department of Chemistry and Chemical Biology, Indian Institute of Technology (ISM) Dhanbad, Jharkhand 826004, India.
³ Department of Chemistry and Chemical Biology, Indian Institute of Technology (ISM) Dhanbad, Jharkhand 826004, India. Electronic address: sagarpal@iitism.ac.in.

PMID: 36746567
DOI: 10.1016/j.carbpol.2023.120576

Abstract

β-CD is a cyclic oligosaccharide, which has trunked cone like structure. The unique structure makes it efficient for numerous applications. Though, the native β-CD has many issues like low solubility, absence of sufficient functionalities and lower complexation ability with guest molecules. One of the most effective paths to increase the efficiency of cyclodextrins is the generation of polycyclodextrins. In this perspective article, we have summarized the recent reports on the synthetic methods towards the modification of β-CD. Besides, this article reviews the current improvements of two types of β-CD centered supramolecular hydrogels: one is supramolecular hydrogels prepared from CD-based poly(pseudo)rotaxanes and the other is supramolecular hydrogels developed through the host-guest interaction between small guest molecules and CDs. The Polycyclodextrins have established noteworthy applications in several areas ranging from adsorbents for organic pollutants removal to effective carriers of bioactive agents.

Keywords: Chemical modification; Hydrogel; Polymers; Supramolecular; β-Cyclodextrin.

Publication types

Review