Recent advances on the synthesis of N-linked glycoprotein for the elucidation of glycan functions

Yanbo Liu; Kota Nomura; Junpei Abe; Yasuhiro Kajihara

doi:10.1016/j.cbpa.2023.102263

Recent advances on the synthesis of N-linked glycoprotein for the elucidation of glycan functions

Curr Opin Chem Biol. 2023 Apr:73:102263. doi: 10.1016/j.cbpa.2023.102263. Epub 2023 Feb 4.

Authors

Yanbo Liu¹, Kota Nomura¹, Junpei Abe¹, Yasuhiro Kajihara²

Affiliations

¹ Department of Chemistry Osaka University, 1-1 Machikaneyama, Toyonaka, 560-0043 Japan.
² Department of Chemistry Osaka University, 1-1 Machikaneyama, Toyonaka, 560-0043 Japan. Electronic address: kajihara@chem.sci.osaka-u.ac.jp.

PMID: 36746076
DOI: 10.1016/j.cbpa.2023.102263

Abstract

Glycoproteins play roles in many biological events, while, the glycan structure-function relationship has remained to be studied. In order to understand glycan function, homogeneous glycoproteins have been synthesized. This review introduced recent progress of their synthetic approaches.

Keywords: Glycan; Glycopeptide; Glycoprotein.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Glycoproteins*
Glycosylation
Polysaccharides*

Substances

Glycoproteins
Polysaccharides