The triglyceride and glucose index and risk of nonalcoholic fatty liver disease: A dose-response meta-analysis

Qin Ling; Jiawei Chen; Xiao Liu; Yi Xu; Jianyong Ma; Peng Yu; Kai Zheng; Fuwei Liu; Jun Luo

doi:10.3389/fendo.2022.1043169

The triglyceride and glucose index and risk of nonalcoholic fatty liver disease: A dose-response meta-analysis

Front Endocrinol (Lausanne). 2023 Jan 19:13:1043169. doi: 10.3389/fendo.2022.1043169. eCollection 2022.

Authors

Qin Ling^{1

2}, Jiawei Chen^{1

2}, Xiao Liu³, Yi Xu^{1

2}, Jianyong Ma⁴, Peng Yu⁵, Kai Zheng⁶, Fuwei Liu¹, Jun Luo¹

Affiliations

¹ Department of Cardiology, the Affiliated Ganzhou Hospital of Nanchang University, Jiangxi, China.
² The Second Clinical Medical College of Nanchang University, Jiangxi, China.
³ Department of Cardiology, the Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.
⁴ Department of Pharmacology and Systems Physiology, University of Cinnati College of Medicine, Cincinnati, OH, United States.
⁵ Department of Endocrine, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
⁶ Medical Care Strategic Customer Department, China Merchants Bank Shenzhen Branch, Shenzhen, China.

Abstract

Background: The triglyceride and glucose (TyG) index is associated with the risk of nonalcoholic fatty liver disease (NAFLD), but the dose-response relationship between them is still unknown. We conducted a comprehensive meta-analysis to study the dose-response association between the TyG index and the risk of NAFLD.

Methods: We systematically searched the Cochrane Library, PubMed, and Embase databases until July 2022 for relevant studies. The robust error meta-regression method was used to investigate the dose-response association between the TyG index and NAFLD. Summary relative risks (ORs) and 95% CIs were estimated by using a random-effects model.

Results: A total of 4 cohort and 8 cross-sectional studies were included, with 28,788 NAFLD cases among the 105,365 participants. A positive association for the risk of NAFLD was observed for each additional unit of the TyG index with a linear association (p=0.82), and the summary OR was 2.84 (95% CI, 2.01-4.01). In the subgroup analyses, a stronger association of the TyG index with NAFLD was shown in females than in males (men: OR=2.97, 95% CI 2.55-3.46, women: OR=4.80, 95% CI 3.90-5.90, P_subgroup<0.001).

Conclusion: The TyG index may be a novel independent risk factor for NAFLD beyond traditional risk factors.

Systematic review registration: https://www.crd.york.ac.uk/prospero, identifier (CRD42022347813).

Keywords: dose-response; meta-analysis; nonalcoholic fatty liver disease; prognosis; triglyceride and glucose index.

Publication types

Meta-Analysis
Systematic Review

MeSH terms

Cross-Sectional Studies
Female
Glucose
Humans
Male
Non-alcoholic Fatty Liver Disease* / epidemiology
Non-alcoholic Fatty Liver Disease* / etiology
Risk Factors
Triglycerides

Substances

Glucose
Triglycerides