The protective effects of lipoxin A4 on type 2 diabetes mellitus: A Chinese prospective cohort study

Sudan Wang; Xiaoyan Qian; Chao Shen; Qian Sun; Yang Jing; Bingyue Liu; Kexin Zhang; Mengyuan Li; Junrong Wang; Hui Zhou; Chen Dong

doi:10.3389/fendo.2023.1109747

The protective effects of lipoxin A4 on type 2 diabetes mellitus: A Chinese prospective cohort study

Front Endocrinol (Lausanne). 2023 Jan 19:14:1109747. doi: 10.3389/fendo.2023.1109747. eCollection 2023.

Authors

Sudan Wang¹, Xiaoyan Qian², Chao Shen², Qian Sun¹, Yang Jing², Bingyue Liu¹, Kexin Zhang¹, Mengyuan Li¹, Junrong Wang¹, Hui Zhou², Chen Dong¹

Affiliations

¹ Department of Epidemiology and Statistics, School of Public Health, Medical College of Soochow University, Soochow, Jiangsu, China.
² Division of non-communicable diseases, Suzhou Industrial Park Centers for Disease Control and Prevention, Soochow, China.

Abstract

Background: Several cellular and animal studies have suggested that lipoxin A4 (LXA4) has a protective effect on type 2 diabetes mellitus (T2DM) development. However, little is known about whether LXA4 influences T2DM development at the population level.

Methods: We included 2755 non-diabetic participants from a cohort study in China who were followed for about seven years. Cox proportional hazards model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CI) for the association between LXA4 and incident T2DM. Mediation models were used to examine how serum lipids as mediators impact the association between LXA4 and T2DM.

Results: In total, 172 newly diagnosed T2DM cases were identified. Multivariate-adjusted HR for T2DM in the fourth compared with the first quartile of LXA4 was 0.62 (95% CI: 0.40-0.96). When used the optimal cutoff value determined by the receiver operating characteristic curve, the results showed participants with LXA4 > 2.84 ng/mL had a decreased T2DM risk compared to those with LXA4 ≤ 2.84 ng/mL (HR: 0.63, 95% CI: 0.45-0.89). The effect of LXA4 on incident T2DM was significantly modified by gender (P _-interaction = 0.024) and family history of diabetes (P _-interaction = 0.025). Additionally, the association between LXA4 and incident T2DM was partially suppressed by the TyG and TG/HDL-c ratio, with a suppression proportion of 22.2% and 16.0%, respectively.

Conclusions: Higher LXA4 levels are significantly associated with a lower risk of T2DM development. The present findings would be helpful in understanding the effect of LXA4 on T2DM development at the population level.

Keywords: cohort study; lipoxin A4; mediation analysis; protective effects; type 2 diabetes mellitus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cohort Studies
Diabetes Mellitus, Type 2*
East Asian People
Humans
Prospective Studies

Substances

lipoxin A4

Grants and funding

This work was supported by the National Natural Science Foundation of China (No. 82173594, 81773507), Key University Science Research Project of Jiangsu Province (21KJA330003), Suzhou science and technology development plan project (SS202009), Suzhou health personnel training project (GSWS2020120), Key technologies of prevention and control of major diseases and infectious diseases in Suzhou City (Gwzx202103).