Roles of Microglia in AD Pathology

Gao Rong; Wu Hongrong; Li Qingqi; Zhao Jianfeng

doi:10.2174/1567205020666230203112351

Roles of Microglia in AD Pathology

Curr Alzheimer Res. 2023;19(13):854-869. doi: 10.2174/1567205020666230203112351.

Authors

Gao Rong¹, Wu Hongrong², Li Qingqi³, Zhao Jianfeng^{1

3}

Affiliations

¹ Department of Physiology, Hengyang Medical School, University of South China, Hengyang, P.R. China.
² Institute of Pathogenic Biology, Hengyang Medical School, University of South China, Hengyang, P.R. China.
³ Institute of Neuroscience, Hengyang Medical School, University of South China, Hengyang, P.R. China.

PMID: 36740796
DOI: 10.2174/1567205020666230203112351

Abstract

Amyloid plaques and neurofibrillary tangles are two main characteristics of Alzheimer's disease (AD). As cerebral resident phagocytes, microglia have different roles in Aβ pathology and tau pathology. In this review, we discuss microglial functions in the formation, clearance, and spread of Aβ and tau. Many receptors and enzymes, which are related to microglia, participate in AD pathologies and thus are thought to be potential targets of AD. So, making use of microglia can be beneficial to confine AD pathologies. To sum up, this article review the roles of microglia in AD pathology and possible corresponding treatments.

Keywords: Alzheimer’s disease; amyloid β; microglia; neurofibrillary tangles; phagocytes; tau.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Alzheimer Disease* / pathology
Amyloid beta-Peptides
Humans
Microglia / pathology
Neurofibrillary Tangles / pathology
tau Proteins

Substances

Amyloid beta-Peptides
tau Proteins