Outcomes and adherence of shorter MDR TB regimen in patients with multidrug resistant tuberculosis

Indian J Tuberc. 2023 Jan;70(1):103-106. doi: 10.1016/j.ijtb.2022.03.021. Epub 2022 Apr 1.

Abstract

Background: In 2016 WHO guidelines conditionally recommended standardized shorter 9-12 months regimen for MDR-TB treatment. The objective is to study outcome analysis of cured, lost to follow-up, treatment completed, treatment failure and mortality of MDR Patients on shorter standardized MDR TB regimen.

Methods: In this prospective study, 360 adults with confirmed Rifampicin Resistant pulmonary TB were studied between March 2018 to February 2020 at Department of Pulmonary Medicine, Guntur Medical College, Govt. Fever Hospital, Guntur.

Results: Among 360 confirmed MDR Patients, 42.50% patients were cured, 41.60% completed treatment, 6.11% of them were lost to follow-up, 0.50% were considered as treatment failure and 9.10% of them were died.

Conclusion: Overall success with a standardized shorter MDR regimen was high with low treatment failure. When introducing shorter regimens base line drug susceptibility testing and minimizing missed doses are critical.

Keywords: Adherence; CBNAAT; LPA; Outcome; Shorter MDR TB.

MeSH terms

  • Adult
  • Antitubercular Agents / therapeutic use
  • Humans
  • Microbial Sensitivity Tests
  • Mycobacterium tuberculosis*
  • Prospective Studies
  • Treatment Outcome
  • Tuberculosis, Multidrug-Resistant* / drug therapy

Substances

  • Antitubercular Agents